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Genetic analysis of HLA and immune escape genes in Diffuse Large B-cell Lymphoma
- Description
Study Description from EGA: "Fifty percent of diffuse large B-cell lymphoma (DLBCL) cases lack cell-surface expression of the class-I major histocompatibility complex (MHC-I), thereby escaping immune recognition by cytotoxic T cells. In order to comprehensively identify the mechanisms involved in MHC-I loss, we first performed immunophenotypic analysis of both MHC class-I and -II in 657 cases across...
- Subject
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beta 2-MicroglobulinHistocompatibility Antigens Class IHLA AntigensLymphoma, Large B-Cell, Diffuse
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- Application Required
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Low-Dose CDK4/6 Inhibitors Induce Presentation of Pathway Specific MHC ligands as Potential Targets for Cancer Immunotherapy
- Authors
- Klatt, Martin GuntherScheinberg, David A.
- Description
Description from PRIDE: "Cyclin dependent kinase 4/6 inhibitors (CDK4/6i) lead to cell-cycle arrest but also trigger T cell-mediated immunity, which might be mediated by the qualitative and quantitative changes in human leukocyte antigen (HLA) ligands on the cancer cell surface. We investigated the effects of CDK4/6i, Abemaciclib and Palbociclib, on the immunopeptidome at subclinical, non-toxic,...
- Subject
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Breast NeoplasmsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p18HLA AntigensT-Lymphocytes
- Access Rights
- Free to All